Aloe Vera

گیاگانی ، گیاه اگیر ترکی

 : Overview 

 Other Names

 

- Aloe Africana;

- Aloe Arborescens;

- Aloe Barbadensis;

- Aloe Capensis;

- Aloe Ferox;

- Aloe Frutescens;

- Aloe Gel;

- Aloe Indica;

- Aloe Latex;

- Aloe Leaf Gel;

- Aloe Natalenis;

- Aloe Perfoliata;

- Aloe Perryi;

- Aloe Spicata;

- Aloe Supralaevis;

- Aloe Ucriae;

- Aloe Vera Barbenoids;

- Aloe Vera Gel;

- Aloes;

- Aloès;

- Aloès De Curaçao;

- Aloès Des Barbades;

- Aloès Du Cap;

- Aloès Vrai;

- Aloès Vulgaire;

- Arborescens Natalenis;

- Barbados Aloe;

- Burn Plant;

- Cape Aloe;

- Chritkumari;

- Curacao Aloe;

- Elephant's Gall;

- Gel De La Feuille D'Aloès;

- Ghee-Kunwar;

- Ghi-Kuvar;

- Ghrita-Kumari;

- Gvar Patha;

- Hsiang-Dan;

- Indian Aloe;

- Jafarabad Aloe;

- Kanya;

- Kidachi Aloe;

- Kumari;

- Latex D'Aloès;

- Lily of the Desert;

- Lu-Hui;

- Miracle Plant;

- Plant of Immortality;

- Plante De L'Immortalité;

- Plante De La Peau;

- Plante De Premiers Secours;

- Plante Miracle;

- Plantes Des Brûlures;

- Sábila.

 

 Overview Information

Aloe is a cactus-like plant that grows in hot, dry climates. In the United States, Aloe is grown in Florida, Texas, and Arizona. Aloe produces two substances, gel and latex, which are used for medicines. Aloe gel is the clear, jelly-like substance found in the inner part of the Aloe plant leaf. Aloe latex comes from just under the plant's skin and is yellow in color. Some Aloe products are made from the whole crushed leaf, so they contain both gel and latex. The Aloe that is mentioned in the Bible is an unrelated fragrant wood used as incense.

Aloe medications can be taken by mouth or applied to the skin. People take Aloe products by mouth for conditions such as obesity, diabetes, osteoarthritis, and many others, but there is no good scientific evidence to support these uses. People apply Aloe gel to the skin for conditions such as acne, dandruff, wound healing, and many others, but there is no good scientific evidence to support these uses.

 

 How Does It Work?

The useful parts of Aloe are the gel and latex. The gel is obtained from the cells in the center of the leaf; and the latex is obtained from the cells just beneath the leaf skin.

Aloe gel might cause changes in the skin that might help diseases like psoriasis.

Aloe seems to be able to speed wound healing by improving blood circulation through the area and preventing cell death around a wound.

It also appears that Aloe gel has properties that are harmful to certain types of bacteria and fungi.

Aloe latex contains chemicals that work as a laxative.

 : Uses & Effectiveness 

 Possibly Effective for:

 

© Acne

Research suggests that applying an Aloe gel in the morning and evening, in addition to a prescription anti-acne medicine, improves acne by about 35% in both children and adults.

 

© Burns

Most research shows that applying Aloe gel or cream to the skin can reduce healing time in people with first- or second-degree burns. Some research also shows that applying Aloe cream reduces wound size compared to applying antibiotics in people with first- or second-degree burns. Also applying cream that contains Aloe to the skin twice daily appears to improve itching and reduce skin picking compared to applying corticosteroid medication in people with chemical burns.

 

© Constipation

Taking Aloe latex by mouth can reduce constipation and also cause diarrhea.

 

© Diabetes

Most research shows that taking Aloe by mouth can reduce blood sugar and HbA1c in people with type 2 diabetes. Aloe also seems to improve cholesterol levels in people with this condition. But it is not clear which dose or form of Aloe works best.

 

© Genital Herpes

Evidence shows that applying an Aloe extract 0.5% cream three times daily increases healing rates in men with genital herpes.

 

© An Inflammatory Condition that Causes Rash or Sores on the Skin or Mouth (Lichen Planus)

Research shows that using a mouthwash containing Aloe gel three times daily for 12 weeks or applying a gel containing Aloe gel twice daily for 8 weeks can reduce pain associated with itchy rashes in the mouth. Other research shows that using a mouthwash containing Aloe four times daily for one month or applying an Aloe gel three times daily for 2 months reduces pain and increases healing similarly to the corticosteroid triamcinolone acetonide in people with itchy rashes in the mouth.

 

© Obesity

Research shows that taking a specific Aloe product (Aloe QDM complex, Univera Inc.) twice daily for 8 weeks reduces body weight and fat mass in overweight or obese people with diabetes or prediabetes.

 

© A Painful Mouth Disease that Reduces Ones Ability to Open the Mouth (Oral Submucous Fibrosis)

Early research in people with oral submucous fibrosis shows that applying Aloe gel reduces burning. But it does not seem to improve the ability to open the mouth or improve cheek and tongue movements.

 

© Scaly, Itchy Skin (Psoriasis)

Applying a cream containing 0.5% Aloe extract for 4 weeks seems to reduce the skin plaques. Also applying cream containing Aloe gel seems to decrease the severity of psoriasis better than the corticosteroid triamcinolone. But using an Aloe gel does not seem to improve other symptoms associated with psoriasis, including skin redness.

 

 Possibly Ineffective for:

 

© Burning Pain in the Mouth

Applying Aloe gel to sore areas on the tongue three times daily before wearing a tongue protector for 12 weeks does not appear to improve pain or reduce symptoms in people with burning mouth syndrome.

 

© HIV/AIDS

Early research suggests that taking 400 mg of a chemical that comes from Aloe four times daily does not improve immune function in people with human immunodeficiency virus (HIV). Also, eating 30-40 mL of Aloe gruel does not improve immune function in people with HIV compared to antiretroviral therapy.

 

© Skin Damage Caused by Radiation Therapy (Radiation Dermatitis)

Most research shows that applying Aloe gel to the skin during and after radiation treatment does not reduce skin damage caused by the radiation, although it might delay the appearance of skin damage. Some early research suggests that applying a specific cream product (Radioskin 2, Herbalab di Perazza Massimiliano Company) to the skin two to three times daily at least 3 hours before and after radiation treatment from 15 days before the start of treatment until one month after, along with another specific cream product (Radioskin 1, Herbalab di Perazza Massimiliano Company), might improve skin hydration and reduce skin damage caused by radiation therapy in people with breast cancer. But it's not clear if the effects of these creams are related to Aloe or other ingredients in the creams.

 

 Insufficient Evidence for:

 

© Dry Socket (Alveolar Osteitis)

Research shows that applying a specific product (SaliCept patch) containing acemannan, a chemical from Aloe, to the tooth socket of people with dry sockets after standard treatment, reduces pain and improves symptoms more than standard treatment alone.

 

© Small tears in the Lining of the Anus (Anal Fissures)

Early research suggests that applying an Aloe cream (Zarban Phyto-Pharmaceutical Co, Iran) three times daily for at least 3 weeks, along with sitz bath three times daily, using a laxative, and eating a full fiber diet, improves pain, wound healing, and bleeding in people with anal fissures.

 

© Cancer

Early research suggests that, when given with standard chemotherapy, three daily doses of a mixture containing fresh Aloe leaves and honey dissolved in alcohol increases the number of patients with lung cancer who are able to heal completely, partially, or maintain control of their disease when compared to just chemotherapy alone. However, taking Aloe does not seem to be linked with a lower risk of getting lung cancer.

 

© Canker Sores

Early research suggests that using a wound dressing containing acemannan, a chemical that comes from Aloe, shortens the amount of time needed for canker sores to heal. Also, applying a gel containing acemannan might reduce ulcer size in some patients. But using the corticosteroid triamcinolone acetonide seems to work better. Other research suggests that applying a gel containing Aloe does not seem to increase the length of time between canker sores.

 

© Tooth Plaque

Some early research suggests that using a toothpaste containing Aloe daily for 24 weeks reduces plaque. Other research evaluating a specific Aloe-containing toothpaste (Forever Bright, Forever Living Products) found it to be comparable to a toothpaste that contains fluoride at reducing plaque.

 

© Foot Sores in People with Diabetes

Early research suggests that applying a gel containing Aloe and great plantain twice daily for 4 weeks might improve healing and reduce ulcer size in people with mild to moderate diabetic foot ulcers also taking oral antibiotics.

 

© Diaper Rash

Early research suggests that applying a cream containing Aloe gel and olive oil three times daily for 10 days reduces the severity of diaper rash in children younger than 3-years-old.

 

© Dry Skin

Early research suggests that applying a cream containing Aloe extract to the skin for 2 weeks increases the amount of water in the outermost later of the skin, but not on the inner layers. Other research suggests that wearing gloves coated in Aloe improves symptoms of dry skin in women. However, it is not clear if the benefits were from the Aloe or the gloves. Some research shows that eating a yogurt containing Aloe Vera gel powder daily for 12 weeks improves dry skin and increases the amount of water in the outermost layer of the skin.

 

© Frostbite

When applied to the skin, Aloe gel seems to help skin survive frostbite injury.

 

© A Mild form of Gum Disease (Gingivitis)

Some research shows that using a specific Aloe-containing toothpaste (Forever Bright, Forever Living Products) is comparable to a toothpaste that contains fluoride at reducing gingivitis. Other research suggests that using a toothpaste containing Aloe daily for 24 weeks reduces gingivitis, but not as well as a toothpaste the contains the drug triclosan.

 

© Swelling (Inflammation) of the Liver (Hepatitis)

Early evidence suggests that taking Aloe three times daily for 12 weeks reduces symptoms of hepatitis in people with liver fibrosis mainly caused by hepatitis B or C.

 

© Insect Repellent

Applying a product (Zanzarin, Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany) containing coconut oil, jojoba oil, and Aloe to the feet twice daily for one week intervals seems to reduce the number of sand fleas in people with flea infestations.

 

© Swelling (Inflammation) and Sores inside the Mouth (Oral Mucositis)

Some evidence suggests that using an Aloe solution three times daily during radiation therapy lowers the risk of developing painful inflammations in the mouth.

 

© Bed Sores (Pressure Ulcers)

Some early research suggests that applying Aloe gel does not improve the healing rate of bedsores compared to using gauze moistened with salt water. But other research suggests that using a salt water spray containing Aloe and other ingredients does reduce the severity of sores compared to a control salt water spray. Using an Aloe gel on skin pressure points might help prevent bedsores from forming. But more research is needed to confirm.

 

© Inflammation and Damage to the Rectum due to Radiation Therapy

Early research shows that applying Aloe Vera gel powder twice daily to the rectal area for 4 weeks can reduce rectal symptoms caused by radiation to the pelvic area.

 

© Itchy Skin IOnfection Caused by Mites (Scabies)

Early research suggests that Aloe gel might reduce itching and wounds similar to benzyl benzoate lotion in people with scabies.

 

© Rough, Scaly Skin on the Scalp and Face (Seborrheic Dermatitis)

Early research suggests that applying Aloe twice daily for 4-6 weeks improves dandruff.

 

© Stretch Marks

Applying Aloe twice daily starting at week 16-18 of pregnancy might improve redness and itching related to stretch marks in women pregnant with their first child. But it doesn't seem to reduce the number of stretch marks that form.

 

© A Type of Inflammatory Bowel Disease (Ulcerative Colitis)

Early research suggests that some people with mild to moderate ulcerative colitis who take Aloe gel by mouth for 4 weeks have significantly reduced symptoms.

 

© Wound Healing

There is conflicting information about whether applying Aloe improves wound healing. Some research shows that applying an Aloe cream to hemorrhoid-related wounds improves wound healing and provides some pain relief. Other research shows that applying Aloe gel under a dry gauze to a caesarean wound improves initial healing compared to applying dry gauze alone. But there is conflicting evidence about the effects of Aloe on the healing of skin graft wounds. Furthermore, some research shows that applying Aloe doesn't affect wound healing and may actually delay wound healing. The conflicting results may be due to differences in products used or application methods.

 

© Asthma

-

 

© Bleeding

-

 

© Colds

-

 

© Depression

-

 

© Epilepsy

-

 

© Glaucoma

-

 

© Lack of a Menstrual Period

-

 

© Multiple Sclerosis

-

 

© Varicose Veins

-

 

© Vision Problems

-

 

© Other Conditions

-

More evidence is needed to rate Aloe for these uses.

 : Side Effects & Safety 

 When Taken by Mouth:

Aloe gel is POSSIBLY SAFE when taken appropriately, short-term. Aloe gel has been used safely in a dose of 15 mL daily for up to 42 days. Also, a specific gel complex (Aloe QDM complex Univera Inc) has been used safely at a dose of about 600 mg daily for up to 8 weeks.

Taking Aloe latex or Aloe whole-leaf extract by mouth is POSSIBLY UNSAFE at any dose. Aloe latex is LIKELY UNSAFE when taken by mouth in high doses. Aloe latex can cause some side effects such as stomach pain and cramps. Long-term use of large amounts of Aloe latex might cause diarrhea, kidney problems, blood in the urine, low potassium, muscle weakness, weight loss, and heart disturbances. Taking Aloe latex 1 gram daily for several days can be fatal. Also, there is concern that chemicals in Aloe latex and/or Aloe whole-leaf extract may promote the development of cancer.

There have been a few reports of liver problems in some people who have taken an Aloe leaf extract; however, this is uncommon. It is thought to only occur in people who are extra sensitive (hypersensitive) to Aloe.

 

 When Applied to the Skin

Aloe gel is LIKELY SAFE when applied to the skin appropriately as a medicine or as a cosmetic.

 

Ø Special Precautions & Warnings:

 

© Pregnancy and Breast-Feeding

Aloe -- either gel or latex -- is POSSIBLY UNSAFE when taken by mouth. There is a report that Aloe was associated with miscarriage. It might also increase the risk for birth defects. Do not take Aloe by mouth if you are pregnant or breast-feeding.

 

© Children

Aloe gel is POSSIBLY SAFE when applied to the skin appropriately. Aloe latex and Aloe whole leaf extracts are POSSIBLY UNSAFE when taken by mouth in children. Children younger than 12 years-old might have stomach pain, cramps, and diarrhea.

 

© Diabetes

Some research suggests that Aloe might lower blood sugar. If you take Aloe by mouth and you have diabetes, monitor your blood sugar levels closely.

 

© Intestinal Conditions such as Crohn's Disease, Ulcerative Colitis, or Obstruction

Do not take Aloe latex if you have any of these conditions. Aloe latex is a bowel irritant. Remember, products made from whole Aloe leaves will contain some Aloe latex.

 

© Hemorrhoids

Do not take Aloe latex if you have hemorrhoids. It could make the condition worse. Remember, products made from whole Aloe leaves will contain some Aloe latex.

 

© Kidney Problems

High doses of Aloe latex have been linked to kidney failure and other serious conditions.

 

© Surgery

Aloe might affect blood sugar levels and could interfere with blood sugar control during and after surgery. Stop taking Aloe at least 2 weeks before a scheduled surgery.

 

 Interactions

 Major Interaction

Do not take this combination:

 

© Digoxin (Lanoxin) Interacts with Aloe

When taken by mouth Aloe latex is a type of laxative called a stimulant laxative. Stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin).

 

 Moderate Interaction

Be cautious with this combination:

 

© Medications for Diabetes (Antidiabetes Drugs) Interacts with Aloe

Aloe gel might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking Aloe gel along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include:

- Glimepiride (Amaryl);

- Glyburide (DiaBeta, Glynase PresTab, Micronase);

- Insulin;

- Pioglitazone (Actos);

- Rosiglitazone (Avandia);

- Chlorpropamide (Diabinese);

- Glipizide (Glucotrol);

- Tolbutamide (Orinase);

- and Others.

 

© Medications Taken by Mouth (Oral Drugs) Interacts with Aloe

When taken by mouth Aloe latex is a laxative. Laxatives can decrease how much medicine your body absorbs. Taking Aloe latex along with medications you take by mouth might decrease the effectiveness of your medication.

 

© Sevoflurane (Ultane) Interacts with Aloe

Aloe might decrease clotting of the blood. Sevoflurane is used as anesthesia during surgery. Sevoflurane also decreases clotting of the blood. Taking Aloe before surgery might cause increased bleeding during the surgical procedure. Do not take Aloe by mouth if you are having surgery within 2 weeks.

 

© Stimulant Laxatives Interacts with Aloe

When taken orally Aloe latex is a type of laxative called a stimulant laxative. Stimulant laxatives speed up the bowels. Taking Aloe latex along with other stimulant laxatives could speed up the bowels too much and cause dehydration and low minerals in the body.

Some stimulant laxatives include:

- Bisacodyl (Correctol, Dulcolax);

- Cascara;

- Castor Oil (Purge);

- Senna (Senokot);

- and Others.

 

© Warfarin (Coumadin) Interacts with Aloe

When taken orally, Aloe latex is a type of laxative called a stimulant laxative. Stimulant laxatives speed up the bowels and can cause diarrhea in some people. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. If you take warfarin, do not to take excessive amounts of Aloe latex.

 

© Water Pills (Diuretic Drugs) Interacts with Aloe

When taken by mouth Aloe latex is a laxative. Some laxatives can decrease potassium in the body. “Water pills” can also decrease potassium in the body. Taking Aloe latex along with “water pills” might decrease potassium in the body too much.

Some “water pills” that can decrease potassium include:

- Chlorothiazide (Diuril);

- Chlorthalidone (Thalitone);

- Furosemide (Lasix);

- Hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide);

- and Others.

 

 Dosing

The following doses have been studied in scientific research:

 Adults

 

© By Mouth:
Q For Constipation

100-200 mg of Aloe or 50 mg of Aloe extract taken in the evening has been used. Also, a 500 mg capsule containing Aloe, starting at a dose of one capsule daily and increasing to three capsules daily as required, has been used.

 

Q For Diabetes

The most effective dose and form of Aloe for diabetes is unclear. Multiple doses and forms of Aloe have been used for 4-14 weeks, including powder, extract, and juice. Doses of powder range from 100-1000 mg daily. Doses of juice range from 15-150 mL daily.

 

Q For Obesity

A specific Aloe gel product containing 147 mg of Aloe twice daily for 8 weeks has been used.

 

Q For a Painful Mouth Diseases that Reduces Ones Ability to Open the Mouth (Oral Submucous Fibrosis)

Pure Aloe Vera juice 30 mL twice daily along with applying pure Aloe Vera gel to lesions three times daily for 3 months has been used.

 

 

© Applied to the Skin:
Q For Acne

A 50% Aloe gel has been applied in the morning and evening after washing the face, along with a prescription called tretinoin gel in the evening.

 

Q For Burns

Aloe and olive oil cream, applied twice daily for 6 weeks, has been used. Also, Aloe gel or cream, applied twice or three times daily after changing a wound dressing, or every three days until the burn heals, has been used.

 

Q For Genital Herpes

A cream containing 0.5% Aloe extract, applied three times daily for 5 consecutive days once or twice over a 2-week period, has been used.

 

Q For an Inflammatory Condition that Causes Rash or Sores on the Skin or Mouth (Lichen Planus)

Aloe gel, applied two to three times daily for 8 weeks has been used. Two tablespoons of Aloe mouthwash, swished for 2 minutes and then spit, four times daily for one month has been used.

 

Q For a Painful Mouth Diseases that Reduces Ones Ability to Open the Mouth (Oral Submucous Fibrosis)

5 mg of an Aloe gel applied on each side of the cheeks three times daily for 3 months has been used. Applying pure Aloe Vera gel to lesions three times daily for 3 months has been used along with drinking pure Aloe Vera juice 30 mL twice daily.

 

Q For Scaly, Itchy Skin (Psoriasis)

Aloe extract 0.5% cream applied three times daily for 4 weeks has been used. A cream containing Aloe, applied twice daily for 8 weeks, has been used.

 

 Children

 

© For Acne

A 50% Aloe gel has been applied in the morning and evening after washing the face, along with a prescription called tretinoin gel in the evening.

 

© For A Painful Mouth Disease that Reduces Ones Ability to Open the Mouth (Oral Submucous Fibrosis)

5 mg of an Aloe gel, applied on each side of the cheeks three times daily for 3 months, has been used

(“Aloe”; WebMD).

 : Synonyms 

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 : Useful Plant Parts and How to Use  

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 : Uses  

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 : How to Use  

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 : Prohibition  

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 : Side Effect 

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 : Drug Interaction 

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 : Habitat and Distribution 

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 : Chemical Constituents 

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 : Preservation/Storage 

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 :  Other Descriptions 

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 :  Images 

 :  Abbreviation 

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 :  References 

1 - Giagani herbal research group

Giagani ،  Herbal Research Group

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