Caulophyllum Thalictroides

 : Overview 

 Other Names


- Actée à Grappes Bleu;

- Blue Ginseng;

- Caulophylle;

- Caulophylle Faux-Pigamon;

- Caulophyllum;

- Cohosh Azul;

- Cohosh Bleu;

- Graines à Chapelet;

- Léontice Faux-Pigamon;

- Papoose Root;

- Cohosh Azul;

- Squaw Root;

- Yellow Ginseng.


 Overview Information

Blue Cohosh is a plant. “Cohosh” is from the Algonquin Indian word meaning “rough,” and it refers to the appearance of the roots. The root is used to make medicine. Blue Cohosh is not a safe plant. However, it still is available as a supplement. Sometimes the supplements do not include warnings.

Blue Cohosh is used for stimulating the uterus and starting labor; starting menstruation; stopping muscle spasms; as a laxative; and for treating colic, sore throat, cramps, hiccups, epilepsy, hysterics, inflammation of the uterus, infection of the female organs (pelvic inflammatory disease), over-growth of uterine tissue (endometriosis), and joint conditions.

In foods, the roasted seeds of Blue Cohosh are used as a coffee substitute.


 How Does It Work?

It is thought that Blue Cohosh might have effects similar to the hormone estrogen. It also may narrow the vessels that carry blood to the heart that can decrease oxygen in the heart.

 : Uses & Effectiveness 

 Insufficient Evidence for:


© Constipation



© Hiccups



© Seizures



© Sore Throat



© Starting Labor and Menstruation



© Stomach Cramps



© Other Conditions


More evidence is needed to rate the effectiveness of Blue Cohosh for these uses.

 : Side Effects & Safety 

Blue Cohosh is LIKELY UNSAFE for adults when taken by mouth. It can cause diarrhea, stomach cramps, chest pain, increased blood pressure, increased blood sugar, and other severe side effects.

 Special Precautions & Warnings:


© Pregnancy and Breast-Feeding

It is LIKELY UNSAFE to take Blue Cohosh by mouth during pregnancy. Some of the chemicals in Blue Cohosh can cause birth defects. When taken by the mother late in pregnancy, Blue Cohosh can cause severe heart problems in the newborn baby. It can also be toxic to the mother.

Many midwives still use Blue Cohosh to make childbirth easier, because Blue Cohosh causes the uterus to contract. But this is a dangerous practice, and it should be avoided.


© Heart Conditions

There is concern that Blue Cohosh might worsen some heart conditions. These conditions include chest pain (angina) and high blood pressure. Blue Cohosh might cause blood vessels in the heart to become smaller and decrease oxygen flow to the heart. It might also increase blood pressure and cause rapid heartbeat. Don't use Blue Cohosh if you have a heart condition.


© Diabetes

There is some concern that Blue Cohosh might make diabetes worse. It can raise blood sugar levels in some people who have diabetes.


© Diarrhea

Blue Cohosh might make diarrhea symptoms worse.


© Hormone-Sensitive Conditions such as Breast Cancer, Uterine Cancer, Ovarian Cancer, Endometriosis, or Uterine Fibroids

Blue Cohosh might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use Blue Cohosh.



 Moderate Interaction

Be cautious with this combination:


© Medications for Diabetes (Antidiabetes Drugs) Interacts with Blue Cohosh

Blue Cohosh might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, Blue Cohosh might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include:

- Glimepiride (Amaryl);

- Glyburide (DiaBeta, Glynase PresTab, Micronase);

- Insulin;

- Pioglitazone (Actos);

- Rosiglitazone (Avandia);

- Chlorpropamide (Diabinese);

- Glipizide (Glucotrol);

- Tolbutamide (Orinase);

- and Others.


© Medications for High Blood Pressure (Antihypertensive Drugs) Interacts with Blue Cohosh

Blue Cohosh seems to increase blood pressure. By increasing blood pressure Blue Cohosh might decrease the effectiveness of medications for high blood pressure.

Some medications for high blood pressure include:

- Captopril (Capoten);

- Enalapril (Vasotec);

- Losartan (Cozaar);

- Valsartan (Diovan);

- Diltiazem (Cardizem);

- Amlodipine (Norvasc);

- Hydrochlorothiazide (HydroDiuril);

- Furosemide (Lasix);

- and Many Others.


© Nicotine Interacts with Blue Cohosh

Blue Cohosh contains chemicals that work similarly to nicotine. Taking Blue Cohosh with nicotine might increase the effects and side effects of nicotine.



The appropriate dose of Blue Cohosh depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Blue Cohosh. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using

(“Blue Cohosh”; WebMD).

 : Synonyms 


 : Useful Plant Parts and How to Use  


 : Uses  


 : How to Use  


 : Prohibition  


 : Side Effect 


 : Drug Interaction 


 : Habitat and Distribution 


 : Chemical Constituents 


 : Preservation/Storage 


 :  Other Descriptions 


 :  Images 

 :  Abbreviation 


 :  References 

1 - Giagani herbal research group

Giagani ،  Herbal Research Group

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