Eleutherococcus Senticosus

گیاگانی

 : Overview 

 Other Names

 

- Acanthopanax Obovatus;

- Acanthopanax Obovatus Hoo;

- Acanthopanax Senticosus;

- Buisson Du Diable;

- Ci Wu Jia;

- Ciwujia;

- Ciwujia Root;

- Ciwujia Root Extract;

- Devil's Bush;

- Devil's Shrub;

- Éleuthéro;

- Eleuthero Extract;

- Eleuthero Ginseng;

- Eleuthero Root;

- Eleutherococci Radix;

- Éleuthérocoque;

- Ginseng De Sibérie;

- Ginseng Des Russes;

- Ginseng Root;

- Ginseng Siberiano;

- Ginseng Sibérien;

- Hedera Senticosa;

- North Wu Jia Pi;

- Phytoestrogen;

- Plante Secrète Des Russes;

- Poivre Sauvage;

- Prickly Eleutherococcus;

- Racine D’Eleuthérocoque;

- Racine De Ginseng;

- Racine Russe;

- Russian Root;

- Shigoka;

- Siberian Eleuthero;

- Siberian Ginseng;

- Thorny Bearer of Free Berries;

- Touch-Me-Not;

- Untouchable;

- Ussuri;

- Ussurian Thorny Pepperbrush;

- Wild Pepper;

- Wu Jia Pi;

- Wu-jia.

 

 Overview Information

Eleuthero is a plant. People use the root of the plant to make medicine.

Eleuthero is often called an “adaptogen.” This is a non-medical term used to describe substances that can supposedly strengthen the body and increase general resistance to daily stress.

In addition to being used as an adaptogen, Eleuthero is used for conditions of the heart and blood vessels such as high blood pressure, low blood pressure, hardening of the arteries (atherosclerosis), and rheumaticheart disease.

It is also used for kidney disease, Alzheimer's disease, attention deficit-hyperactivity disorder (ADHD), chronic fatigue syndrome, diabetes, high cholesterol, improving loss of sensation in extremities (peripheral neuropathy), fibromyalgia, rheumatoid arthritis, reducing the effects of a hangover, flu, colds, chronic bronchitis, and tuberculosis. It is also used for treating the side effects of cancerchemotherapy.

Some people use Eleuthero to improve athletic performance and the ability to do work. They also use it to treat sleep problems (insomnia) and the symptoms of infections caused by herpes simplex type 2.

It is also used to boost the immune system, prevent colds, and increase appetite.

In manufacturing, Eleuthero is added to skin care products.

Don't confuse Eleuthero with other types of ginseng. Eleuthero is not the same herb as American or Panax ginseng. Be careful about which product you choose. American and Panax ginseng can be a lot more expensive. It is said that years ago, the Soviet Union wanted to provide its athletes with the advantages offered by ginseng but wanted a less expensive version. So, Eleuthero became popular, and this is why most studies on Eleuthero have been done in Russia.

You should know that the quality of Eleuthero products varies a lot. Eleuthero is often misidentified or contains “adulterants,” which are other ingredients that do not contribute to the benefit of the product, but take up space in the product. Silk vine is a common adulterant of Eleuthero.

Before taking Eleuthero, talk with your healthcare provider if you take any medications. This herb interacts with many prescription drugs..

 

 How Does It Work?

Eleuthero contains many chemicals that affect the brain, immune system, and certain hormones. It might also contain chemicals that have activity against some bacteria and viruses.

 : Uses & Effectiveness 

 Possibly Effective for:

 

© Bipolar Disorder

Taking Eleuthero plus lithium by mouth for 6 weeks appears to induce a similar response rate and remission rate as taking lithium plus fluoxetine in people with bipolar disorder.

 

© Relieving Symptoms of the Common Cold, When Used in Combination with an Herb Called Andrographis

Some clinical research shows that taking a specific combination product containing Eleuthero plus andrographis (Kan Jang, Swedish Herbal Institute) by mouth improves symptoms of the common cold when started within 72 hours of symptom onset. Some symptoms can improve after 2 days of treatment. However, it generally takes 4-5 days of treatment for the maximum benefit. Some research suggests this combination of Eleuthero and andrographis relieves cold symptoms in children better than echinacea. Also taking a specific product containing Eleuthero, echinacea, and malabar nut (Kan Jang, Swedish Herbal Institute) for 6 days appears to improve coughing and congestion better than taking the drug bromohexine.

 

© Diabetes

Taking Eleuthero extract appears to decrease blood glucose levels in people with type 2 diabetes.

 

© A Viral Infection Called Herpes Simplex 2 (HSV-2)

Taking a specific Eleuthero extract, standardized to contain a specific ginseng ingredient called Eleutheroside 0.3% (Elagen), seems to reduce the number, severity, and duration of herpes simplex type 2 infections.

 

 Insufficient Evidence for:

 

© Improving Athletic Performance

Research on the effects of Eleuthero for improving athletic performance is conflicting. Some research shows that taking a specific Eleuthero product (Endurox) does not seem to improve breathing or heart rate recovery following treadmill, cycling, or stair-stepping exercises. Also, taking a Eleuthero liquid extract that contains chemicals called Eleutheroside B and Eleutheroside E does not appear to improve endurance or performance in trained distance runners. However, other research shows that taking powdered Eleuthero containing these two chemicals might improve breathing and endurance while cycling.

 

© Chronic Fatigue Syndrome

Taking Eleuthero by mouth does not seem to reduce symptoms of chronic fatigue syndrome.

 

© Mental Performance

Early research suggests that Eleuthero might improve memory and feelings of well-being in middle-aged people. Also, taking a combination of rhodiola, schisandra, and Eleuthero (ADAPT-232) seems to improve attention and mental speed and accuracy in women experiencing mental stress.

 

© An Inherited Disorder That Causes Swelling and Fevers (Familial Mediterranean Fever)

Early research suggests that taking a combination of Eleuthero, andrographis, schisandra, and licorice (ImmunoGuard, Inspired Nutritionals) reduces the duration, number, and severity of attaches of familial Mediterranean fever in children.

 

© Hangover

Early research suggests that taking Eleuthero extract might relieve some symptoms associated with a hangover.

 

© Heart Disease

Early research suggests that injecting Eleuthero intravenously (by IV) might help reduce some risk factors for heart disease, including high cholesterol and an abnormal heart rate.

 

© High Cholesterol

Taking Eleuthero extract appears to decrease triglyceride and total cholesterol levels.

 

© Flu

Early research suggests that taking a specific product containing Eleuthero plus andrographis (Kan Jang, Swedish Herbal Institute) helps relieve symptoms faster and reduce the risk of flu complications better than taking the drug amantadine.

 

© Stress

Early research suggests taking Eleuthero root has no effect on stress levels when taken alone or with stress management training.

 

© Stroke

Early research suggests that injecting Eleuthero intravenously (by IV) might help treat strokes caused by a blockage of blood vessels that supply blood to the brain.

 

© Osteoarthritis

Taking a combination of Panax ginseng, Eleuthero, and rehmannia for 6 weeks seems to improve physical function in people with knee osteoarthritis. However, the combination does not seem to reduce pain or stiffness.

 

© Osteoporosis

Early research suggests that adding rehmannia and Eleuthero to calcium plus vitamin D treatment for one year helps reduce the loss of bone density in the spine and thigh bone in postmenopausal women.

 

© Pneumonia

Early research suggests that taking a combination of rhodiola, schisandra, and Eleuthero (Chisan) along with standard treatment for 10-15 days helps reduce the length of time that antibiotics are needed and may improve quality of life in people with pneumonia better than standard treatment alone.

 

© Quality of life

Some research shows that Eleuthero significantly improves sociability and sense of well-being in people over 65 years of age after 4 weeks of treatment. But the effects seem to disappear after 8 weeks.

 

© Alzheimer's Disease

-

 

© Attention Deficit-Hyperactivity Disorder (ADHD)

-

 

© Bronchitis

-

 

© Chemotherapy Side Effects

-

 

© Fatigue

-

 

© Fibromyalgia

-

 

© Kidney Problems

-

 

© Low Oxygen Levels

-

 

© Motion Sickness

-

 

© Tuberculosis

-

 

© High Cholesterol

-

 

© Other Conditions

-

More evidence is needed to rate Eleuthero for these uses.

 : Side Effects & Safety 

Eleuthero is LIKELY SAFE for most adults when taken by mouth, short-term. While side effects are rare, some people can have drowsiness, changes in heart rhythm, sadness, anxiety, muscle spasms, and other side effects. In high doses, increased blood pressure might occur.

Eleuthero is POSSIBLY SAFE for most adults when taken by mouth, long-term, or when injected intravenously (by IV), short term. Eleuthero has been taken by mouth in combination with rehmannia, calcium, and vitamin D for up to one year. Eleuthero has been injected by IV for up to 2 weeks.

 Special Precautions & Warnings:

 

© Children

Eleuthero is POSSIBLY SAFE in teenagers (ages 12-17 years) when taken by mouth for up to 6 weeks. There is not enough reliable information about the safety of Eleuthero when taken by teenagers long-term.

 

© Pregnancy and Breast-Feeding

There is not enough reliable information about the safety of taking Eleuthero if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

 

© Bleeding Disorders

Eleuthero contains chemicals that might slow blood clotting. In theory, Eleuthero might increase the risk of bleeding and bruising in people with bleeding disorders.

 

© Heart Conditions

Eleuthero can cause a pounding heart, irregular heartbeat, and high blood pressure. People who have heart disorders (e.g., “hardening of the arteries,” rheumatic heart disease, or history of heart attack) should use Eleuthero only under a healthcare provider's supervision.

 

© Diabetes

Eleuthero might increase or decrease blood sugar. In theory, Eleuthero might affect blood sugar control in people with diabetes. Monitor your blood sugar carefully if you take Eleuthero and have diabetes.

 

© Hormone-Sensitive Conditions such as Breast Cancer, Uterine Cancer, Ovarian Cancer, Endometriosis, or Uterine Fibroids

Eleuthero might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use Eleuthero.

 

© High Blood Pressure

Eleuthero should not be used by people with blood pressure over 180/90. Eleuthero might make high blood pressure worse.

 

© Mental Conditions such as Mania or Schizophrenia

Eleuthero might make these conditions worse. Use with caution.

 

 Interactions

 Moderate Interaction

Be cautious with this combination:

 

© Alcohol Interacts with Eleuthero

Alcohol can cause sleepiness and drowsiness. Siberian ginseng might also cause sleepiness and drowsiness. Taking large amounts of Siberian ginseng along with alcohol might cause too much sleepiness.

 

© Digoxin (Lanoxin) Interacts with Eleuthero

Digoxin (Lanoxin) helps the heart beat more strongly. One person had too much digoxin in their system while taking a natural product that might have had Siberian ginseng in it. But it is unclear if Siberian ginseng or other herbs in the supplement were the cause.

 

© Lithium Interacts with Eleuthero

Siberian ginseng might have an effect like a water pill or “diuretic.” Taking Siberian ginseng might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.

 

© Medications Changed by the Liver [Cytochrome P450 1A2 (CYP1A2) Substrates] Interacts with Eleuthero

Some medications are changed and broken down by the liver.

Siberian ginseng might decrease how quickly the liver breaks down some medications. Taking Siberian ginseng along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking Siberian ginseng talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include:

- Clozapine (Clozaril);

- Cyclobenzaprine (Flexeril);

- Fluvoxamine (Luvox);

- Haloperidol (Haldol);

- Imipramine (Tofranil);

- Mexiletine (Mexitil);

- Olanzapine (Zyprexa);

- Pentazocine (Talwin);

- Propranolol (Inderal);

- Tacrine (Cognex);

- Theophylline;

- Zileuton (Zyflo);

- Zolmitriptan (Zomig);

- and Others.

 

© Medications Changed by the Liver [Cytochrome P450 2C9 (CYP2C9) Substrates] Interacts with Eleuthero

Some medications are changed and broken down by the liver.

Siberian ginseng might decrease how quickly the liver breaks down some medications. Taking Siberian ginseng along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking Siberian ginseng talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include:

- Amitriptyline (Elavil);

- Diazepam (Valium);

- Zileuton (Zyflo);

- Celecoxib (Celebrex);

- Diclofenac (Voltaren);

- Fluvastatin (Lescol);

- Glipizide (Glucotrol);

- Ibuprofen (Advil, Motrin);

- Irbesartan (Avapro);

- Losartan (Cozaar);

- Phenytoin (Dilantin);

- Piroxicam (Feldene);

- Tamoxifen (Nolvadex);

- Tolbutamide (Tolinase);

- Torsemide (Demadex);

- Warfarin (Coumadin);

- and Others.

 

© Medications for Diabetes (Antidiabetes Drugs) Interacts with Eleuthero

Siberian ginseng might affect blood sugar, either lowering or increasing blood sugar levels. Diabetes medications are also used to lower blood sugar. Taking Siberian ginseng along with diabetes medications might cause your blood sugar to go too low or cause your diabetes medication to be less effective. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include:

- Glimepiride (Amaryl);

- Glyburide (DiaBeta, Glynase PresTab, Micronase);

- Insulin;

- Pioglitazone (Actos);

- Rosiglitazone (Avandia);

- Chlorpropamide (Diabinese);

- Glipizide (Glucotrol);

- Tolbutamide (Orinase);

- and Others.

 

© Medications that Slow Blood Clotting (Anticoagulant/ Antiplatelet Drugs) Interacts with Eleuthero

Siberian ginseng might slow blood clotting. Taking Siberian ginseng along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include:

- Aspirin;

- Clopidogrel (Plavix);

- Diclofenac (Voltaren, Cataflam, Others);

- Ibuprofen (Advil, Motrin, Others);

- Naproxen (Anaprox, Naprosyn, Others);

- Dalteparin (Fragmin);

- Enoxaparin (Lovenox);

- Heparin;

- Warfarin (Coumadin);

- and Others.

 

© Sedative Medications (CNS Depressants) Interacts with Eleuthero

Siberian ginseng might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking Siberian ginseng along with sedative medications might cause too much sleepiness.

Some sedative medications include:

- Clonazepam (Klonopin);

- Lorazepam (Ativan);

- Phenobarbital (Donnatal);

- Zolpidem (Ambien);

- and Others.

 

 Minor Interaction

Be watchful with this combination:

 

© Medications Changed by the Liver [Cytochrome P450 2D6 (CYP2D6) Substrates] interacts with Eleuthero

Some medications are changed and broken down by the liver.

Siberian ginseng might decrease how quickly the liver breaks down some medications. Taking Siberian ginseng along with some medications that are change by the liver can increase the effects and side effects of your medication. Before taking Siberian ginseng talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include:

- Amitriptyline (Elavil);

- Clozapine (Clozaril);

- Codeine;

- Desipramine (Norpramin);

- Donepezil (Aricept);

- Fentanyl (Duragesic);

- Flecainide (Tambocor);

- Fluoxetine (Prozac);

- Meperidine (Demerol);

- Methadone (Dolophine);

- Metoprolol (Lopressor, Toprol XL);

- Olanzapine (Zyprexa);

- Ondansetron (Zofran);

- Tramadol (Ultram);

- Trazodone (Desyrel);

- and Others.

 

© Medications Changed by the Liver [Cytochrome P450 3A4 (CYP3A4) Substrates] interacts with Eleuthero

Some medications are changed and broken down by the liver.

Siberian ginseng might decrease how quickly the liver breaks down some medications. Taking Siberian ginseng along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking Siberian ginseng, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include:

- Lovastatin (Mevacor);

- Ketoconazole (Nizoral);

- Itraconazole (Sporanox);

- Fexofenadine (Allegra);

- Triazolam (Halcion);

- and Many Others.

 

 Dosing

The following doses have been studied in scientific research:

 By Mouth

 

© For Herpes Simplex Type 2 Infections

Eleuthero extract standardized to contain Eleutheroside E 0.3% in doses of 400 mg per day.

 

© For the Common Cold

400 mg of a combination of Eleuthero plus a specific andrographis extract, standardized to contain 4-5.6 mg andrographolide (Kan Jang, Swedish Herbal Institute) three times daily

(“Eleuthero”; WebMD).

 : Synonyms 

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 : Useful Plant Parts and How to Use  

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 : Uses  

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 : How to Use  

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 : Prohibition  

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 : Side Effect 

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 : Drug Interaction 

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 : Habitat and Distribution 

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 : Chemical Constituents 

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 : Preservation/Storage 

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 :  Other Descriptions 

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 :  Images 

 :  Abbreviation 

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 :  References 

1 - Giagani herbal research group

Giagani ،  Herbal Research Group

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